魏婉清,博士、副研究员
1991年11月生,安徽淮南人。2019年博士毕业于南京大学化学化工学院物理化学专业。在Nature Chemical Biology、Nature Communications、Angewandte Chemie-International Edition、CCS Chemistry等期刊上以第一作者或通讯作者发表SCI论文9篇。主持江苏省自然科学基金和入选江苏省双创博士。
研究领域:
主要采用多尺度计算模拟探究生物分子的结构、动力学和相互作用;研究生物有机化学反应的机理,阐释反应活性和选择性的基本原理和控制因素;对生物大分子进行理性设计,以改造生物催化剂的活性与选择性。
主要代表性成果:
[1] Shanqing Huang†, Ying Wang†, Chuangxu Cai, Xiuyun Xiao, Shulei Liu, Yeying Ma, Xiangqian Xie, Yong Liang, Hao Chen, Jiapeng Zhu, Julian D. Hegemann*, Hongwei Yao*, Wanqing Wei* and Huan Wang*. Crystal Structure of the Kinase Domain of a Class III Lanthipeptide Synthetase Reveals a Motif Essential for Substrate Binding and Domain Interaction. Angew. Chem. Int. Ed. 2022. e202211382.
[2] Hong Jie Zhu†, Bo Zhang†, Wanqing Wei†, Shuang He Liu, Lang Xiang, Jiapeng Zhu, Rui Hua Jiao, Ya-suhiro Igarashi, Ghader Bashiri, Yong Liang*, Ren Xiang Tan*, Hui Ming Ge*. AvmM Catalyses Macrocyclization through Dehydra-tion/Michael-type Addition in Alchivemycin a Biosynthesis. Nat. Commun. 2022, 13, 4499.
[3] Chang Zhao†, Wangjian Sheng†, Ying Wang, Jie Zheng, Yong Liang, Wanqing Wei*, Rui Bao* and Huan Wang*. Remodeling of Conformational Dynamics Enhances Catalytic Activities of M1 Zinc-metallopeptidases from Lanthipeptide Biosynthesis. Nat. Chem. Biol. 2022. DOI: 10.1038/s41589-022-01018-2.
[4] Xuan Wu, Yu Chen, Xin Wang, Wanqing Wei* and Yong Liang*. Origin of Site Selectivity in Toluene Hydroxylation by Cytochrome P450 Enzymes. J. Org. Chem. 2021, 86, 13768.
[5] Fangting Wang†, Wanqing Wei†, Junfeng Zhao, Tianlu Mo, Xin Wang, Xuedong Huang, Suze Ma, Shu Wang, Zixin Deng, Wei Ding, Yong Liang* and Qi Zhang*. Genome Ming and Biosynthesis Study of a Type B Linaridin Reveals a Highly Versatile α-N-Methyltransferase. CCS Chem. 2020, 2, 1.
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