魏婉清，副研究员、硕士生导师
安徽淮南人，江南大学至善青年学者。博士毕业于南京大学化学化工学院物理化学专业。已主持包括国家自然科学基金青年、重点研发计划子课题、江苏省自然科学基金在内的国家或省部级课题3项。研究成果在Nat Catal、Nat Chem Biol、Nat Commun等学术期刊发表论文20余篇，申请或授权中国发明专利30余项。入选江苏省双创博士，获教育部科技进步一等奖(排4)。
研究领域：
理论计算指导下金属铁酶的天然功能拓展和新功能开发
主要代表性成果：
[1] He Jun-Bin†, Wu Lian†, Wei Wanqing†, Meng Song, Liu Zheng-Tao, Wu Xuan, Pan Hai-Xue, Yang Sheng, Liang Yong*, Zhou Jiahai*, Tang Gong-Li*. Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis. Nature Catalysis. 2023, 6:637-648.
[2] Zhao Chang†, Sheng Wangjian†, Wang Ying, Zheng Jie, Xie Xiangqian, Liang Yong, Wei Wanqing*, Bao Rui*, Wang Huang*. Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases. Nature Chemical Biology. 2022,18(7):724-732.
[3] Wu Lian†, He Jun-Bin†, Wei Wanqing†, Pan Hai-Xue, Wang Xin, Yang Sheng*, Liang Yong*, Tang Gong-Li*, Zhou Jiahai*. Three distinct strategies lead to programmable aliphatic C-H oxidation in bicyclomycin biosynthesis. Nature Communications. 2025, 16:4651.
[4] Zhu Hong Jie†, Zhang Bo†, Wei Wanqing†, Liu Shuang He, Xiang Lang, Zhu Jiapeng, Jiao Rui Hua, Igarashi Yasuhiro, Bashiri Ghader, Liang Yong*, Tan Ren Xiang*, Ge Hui Ming*. AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis. Nature Communications. 2022,13(1):4499.
[5] Zhang Ze†, Wei Wanqing†, Chen Siqi†, Yang Jintao, Song Dongfan, Chen Yinghan, Zhao Zerun, Chen Jiawen, Wang Fulong, Wang Jiahuan, Li Zhe, Liang Yong*, Yu Hanyang*. Chemoenzymatic installation of site-specific chemical groups on DNA enhances the catalytic activity. Journal of the American Chemical Society. 2024,146(10):7052-7062.
[6] Yang Yu Meng†, Zhao Er Juan†, Wei Wanqing†, Xu Zi Fei, Shi Jing, Wu Xuan, Zhang Bo, Igarashi Yasuhiro, Jiao Rui Hua, Liang Yong*, Tan Ren Xiang*, Ge Hui Ming*. Cytochrome P450 catalyzes benzene ring formation in the biosynthesis of trialkyl-substituted aromatic polyketides. Angewandte Chemie International Edition. 2023, 62(5):e202214026.
[7] Huang Shanqing†, Wang Ying†, Cai Chuangxu, Xiao Xiuyun, Liu Shulei, Ma Yeying, Xie Xiangqian, Liang Yong, Chen Hao, Zhu Jiapeng, Hegemann Julian D*, Yao Hongwei*, Wei Wanqing*, Wang Huan*. Discovery of a unique structural motif in lanthipeptide synthetases for substrate binding and interdomain interactions. Angewandte Chemie International Edition. 2022, 61(45):e202211382.
[8] Wang Zi-Long†, Wei Wanqing†, Wang Hai-Dong†, Zhou Jia-Jing, Wang Hao-Tian, Chen Kuan, Wang Rong-Shen, Li Fu-Dong, Qiao Xue, Zhou Huan*, Liang Yong*, Ye Min*. Functional characterization, structural basis, and regio-selectivity control of a promiscuous flavonoid 7,4'-di-O-glycosyltransferase from Ziziphus jujuba var. spinosa. Chemical Science. 2023,14(16):4418-4425.
[9] He Zhizhen, Han Yeting, Song Wei, Gao Cong, Li Xiaomin, Wei Wanqing*, Wu Jing*. A platform efficiently produces aliphatic, aromatic, and heterocyclic primary diamines from alcohols. Green Chemistry. 2025, 27:7950.
[10] Meng Weiwei, Gao Mengjian, Li Lulu, Liu Liming, Li Xiaomin, Wei Wanqing*, Wu Jing*. Redesigning chondroitin 6-O-sulfotransferase for efficient whole-cell biosynthesis of chondroitin sulfate C. Bioresource Technology. 2026, 449:13497.
联系邮箱：wanqwei@163.com
